Mental health
Women with endometriosis genetically predisposed to depression, anxiety and eating disorders- study
Yale study finds having endometriosis significantly increases the odds of having other psychiatric conditions

Women suffering from endometriosis may be genetically predisposed to depression, anxiety and eating disorders, Yale researchers have found.
The largest epidemiological study to date on the psychiatric factors that can accompany endometriosis has demonstrated that depression, anxiety, and eating disorders are not only a result of the chronic pain endometriosis generates, but also have their own underlying genetic mechanisms.
One in ten women lives with endometriosis, a chronic condition where endometrial-like tissue grows outside the uterus. Some may experience flare ups while menstruating, while others live with daily symptoms.
The World Health Organization (WHO) estimates that “at least” six and a half million women in the US alone have the condition, a figure that rises to as high as 190 million globally.
The new study, published in JAMA Network Open, obtained data from the UK Biobank which included more than 8,200 patients with endometriosis and 194,000 healthy controls.
First, researchers investigated if depression, anxiety, and eating disorders were more prevalent in those with endometriosis, accounting for chronic pain, socioeconomic status, age, body mass index, various medications, and co-morbid conditions.
They found that having endometriosis significantly increases the odds of having these three psychiatric conditions.
Next, the team explored the underlying genetics of this association. Through running a genetic correlation analysis, they found a significantly high genetic correlation between endometriosis and each of the three disorders.
They further conducted an analysis to identify the shared genetic variants, uncovering a variant shared between endometriosis and depression. The gene is one highly expressed in many brain regions as well as female reproductive tissue.
‘Far beyond reproduction’
Renato Polimanti, associate professor of psychiatry and the study’s principal investigator, said: “The relationship between endometriosis and mental health is more complicated than we expected.
“The biological basis is not just chronic pain, and there is much more that we need to understand.”
Dora Koller, a postdoctoral researcher in computational genomics and first author whose inspiration for the study stems in part from her own journey with the condition, said: “For a long time, researchers thought it was just a gynaecological disease—that it didn’t affect anything but female reproduction, and so women were often only treated when they presented with infertility.
“But we have to acknowledge that the effects of endometriosis extend far beyond reproduction.”
Dr Hugh Taylor, chair and Anita O’Keeffe Young Professor of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine and a co-author on the study, added: “It’s not surprising that having a genetic predisposition to endometriosis might include genetic alterations that affect other areas of the body as well.”
Epidemiological studies have long revealed a correlation between endometriosis and mental health disorders, Taylor explained, but researchers’ past explanation of this relationship was “often irresponsible” and shifted the blame onto the patients.
“Correlation does not prove cause and effect. The inappropriate, wrong, and hurtful interpretation was often, ‘these are anxious people complaining about pain that all women have.’ They were wrong.”
The team hopes its current study will help raise awareness about the lesser known, far-reaching manifestations of endometriosis.
“It’s important for the public and healthcare providers to know there’s a common risk for endometriosis and mood disorders,” Taylor said.
“Going back to the history of endometriosis, it has far too often been blamed on the patient—you’re too thin, you’re too anxious, you complain too much. It is not that. You are at increased risk for all of these conditions simultaneously based on your genetic makeup.”
Pregnancy
More than half of women with gestational diabetes face harmful stigma, research reveals

More than half of women with gestational diabetes report stigma from healthcare staff, family, friends and wider society, new research shows.
A survey of 1,800 UK women found widespread emotional distress at diagnosis of the condition, a form of high blood sugar that develops during pregnancy, with effects lasting beyond birth.
Gestational diabetes affects around one in 20 pregnancies in the UK, and the findings highlight the wider toll on women diagnosed with the condition.
The study was funded by Diabetes UK and led by researchers at King’s College London and University College Cork.
Dr Elizabeth Robertson, director of research and clinical at Diabetes UK, said: “Stigma can have a dangerous and devastating impact on pregnant women diagnosed with gestational diabetes, particularly at a time when emotions and anxieties may already be heightened.
“We know that stigma can lead to shame, isolation and poorer mental health, and may discourage people from attending healthcare appointments, potentially increasing the risk of serious complications.
“This research highlights the urgent need for better support systems, based on understanding and empathy to ensure no one feels blamed or judged during their pregnancy.”
More than two-thirds of women, 68 per cent, reported anxiety at diagnosis, while 58 per cent felt upset and 48 per cent experienced fear.
The psychological impact continued beyond birth, with 61 per cent saying the condition negatively affected their feelings about future pregnancies.
Nearly half of women, 49 per cent, felt judged for having gestational diabetes, while 47 per cent felt judged because of their body size.
More than 80 per cent felt other people did not understand gestational diabetes, and more than a third, 36 per cent, concealed their diagnosis from others.
Gestational diabetes stigma was also common in healthcare settings, with 48 per cent reporting that professionals made assumptions about their diet and exercise, and more than half, 52 per cent, feeling judged based on their blood glucose results.
Many women described a loss of control and a sense of disruption during pregnancy.
Nearly two-thirds, 64 per cent, felt they were denied a normal pregnancy, while 76 per cent reported a lack of control over their pregnancy.
More than a third, 36 per cent, felt abandoned by healthcare services after giving birth, and one in four, 25 per cent, continued to experience depression or anxiety postpartum.
Focus group participants described harmful stereotypes, including assumptions that they were ‘lazy’, had ‘poor eating habits’ or ‘lacked willpower’.
Comments from family and friends included remarks such as “should you be eating that?” and “you must have eaten too much, that’s why you have gestational diabetes.”
The researchers are calling for targeted interventions alongside structured emotional support for women during and after pregnancies affected by gestational diabetes, to improve both mental and physical health outcomes.
Professor Angus Forbes, lead researcher from King’s College London, said: “Stigma and emotional distress are far more common in women diagnosed with gestational diabetes than many realise.
“Everyday interactions, even with those who mean well, can deepen this harm, shaping women’s emotional wellbeing and the choices they feel able to make.
“It’s clear that meaningful action is needed to protect women’s mental and physical health.”
Risk factors for gestational diabetes include living with overweight or obesity, having a family history of type 2 diabetes, and being from a South Asian, Black or African Caribbean or Middle Eastern background.
Mental health
Lifting weights shows mental health and cognitive benefits in older women, study finds

Weightlifting can improve memory and mental health in older women, whether they lift heavier or lighter weights, a clinical trial has found.
The study suggests structured exercise could offer a non-drug way to help protect the ageing mind.
As people age, physical abilities often decline and the risk of cognitive impairment rises.
Women can also face a higher risk of depression and anxiety later in life because of menopause, hormonal changes and shifting social factors.
Over time, poor mental health can speed up physical and cognitive decline.
Medical professionals often recommend cardiovascular and resistance training to help preserve physical independence.
Beyond building muscle and strength, lifting weights may also help protect the brain.
The research team recruited 120 women with an average age of 68 who were not taking part in any structured exercise programmes.
Before the intervention, independent cardiologists screened the volunteers using diagnostic stress tests to make sure they could take part safely.
The researchers then divided the women into three equal groups based on their baseline physical strength to ensure a balanced comparison.
The first group followed a resistance training programme using heavier weights for eight to 12 repetitions.
The second performed the same exercises using slightly lighter weights for 10 to 15 repetitions. The third acted as a control group and remained sedentary throughout the trial.
For three months, the active groups visited the university fitness facility three mornings a week.
Under the direct supervision of qualified fitness experts, participants completed three sets of eight different full-body exercises. These included weight machines and free weights, with movements such as chest presses, leg extensions, seated rows and bicep curls.
As the women grew stronger over the 12 weeks, supervisors progressively increased the weight they lifted.
This ensured participants stayed within their assigned repetition range while maintaining proper breathing and movement technique. Researchers also told all participants not to start any new exercise outside the laboratory setting.
The scientists carried out a broad set of cognitive and psychological tests before the programme began and again shortly after it ended.
They used the Montreal Cognitive Assessment to measure spatial skills, short-term memory and language processing.
The team also used several standardised surveys to track symptoms of geriatric depression and general anxiety.
Other tests assessed executive function, the mental processes involved in planning, focusing attention and multitasking.
In the Trail Making Test, the women had to connect a scattered sequence of numbers and letters as quickly as possible to assess cognitive flexibility.
In another verbal test, they had to name as many words beginning with the letter F, or as many animals as possible, within 60 seconds.
The researchers also used a computerised Stroop test to assess inhibitory control. In this visual test, the women saw words such as “red” or “black” displayed in conflicting ink colours, such as green.
They had to suppress the automatic urge to read the word and instead press a button matching the ink colour.
After the three-month intervention, both groups of weightlifters showed clear improvements in their test scores.
Their performance on the overall cognitive assessment rose, and their reaction times in executive function tests fell substantially.
The control group showed no such improvements, and in some categories their mental performance worsened slightly.
The structured exercise also reduced the severity of mood disorders among the active participants.
Scores for depressive symptoms fell by roughly 34 per cent in the lower repetition group and 24 per cent in the higher repetition group. Anxiety scores fell by more than 40 per cent in both groups.
The researchers said these improvements met the threshold for a clinically meaningful difference.
In practical terms, that means the psychological benefits were large enough for the women to notice in their daily emotional state.
The trial found no major differences in outcomes between the two repetition strategies, suggesting both intensities worked equally well against cognitive decline.
The study has several caveats that may shape future research into the neurological benefits of structured exercise.
The testing relied heavily on self-reported psychological surveys, which can be affected by subjective bias or temporary changes in mood.
The team also did not closely track differences in the women’s light daily physical activity outside the gym.
The researchers also said the social structure of the fitness programme may have contributed to the emotional benefits.
For 12 weeks, the active participants exercised in a shared, supportive environment, with regular contact with peers and supervisors.
This kind of consistent social interaction can help reduce loneliness and provide psychological relief.
Future trials will need to isolate whether different exercise durations or extra social interaction change these positive neural effects.
Even so, the results suggest resistance training could offer an accessible way to help treat mild cognitive and mood problems.
Regular weightlifting may benefit the mind as well as the muscles in older adults.
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