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Record numbers of women are freezing their eggs, data shows

Egg and embryo freezing cycles are the fastest growing treatments in the UK

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More people than ever before are having fertility treatment as new data shows a 64 per cent increase in egg freezing and fertility preservation cycles.

The Fertility Treatment 2021: Preliminary Trends and Figures report, published by the Human Fertilisation & Embryology Authority (HFEA), has shown that around 55,000 patients had IVF or donor insemination treatment at UK licensed fertility clinics in 2021, compared to 53,000 in 2019.

The data has found that 83,000 IVF and donor insemination cycles were carried out in 2021 compared to 76,000 in 2019.

It has also revealed record numbers of patients are freezing their eggs for future use with 4,000 in 2021 compared to around 2,500 in 2019 (a 64 per cent rise).

The report, which shows how many patients undergo fertility treatment each year in UK fertility clinics, the type of treatment they have and the success rate, also shows the average pregnancy rate from IVF.

It suggests pregnancy rates using fresh embryo transfers have increased, rising to 29 per cent per embryo transferred in 2021 from 10 per cent in 1991.

“Overall, the new HFEA report paints a promising picture,” says Julia Chain, chair of the Human Fertilisation & Embryology Authority (HFEA).

“It shows treatment numbers are back at pre pandemic levels and thanks to improved clinical and laboratory practice, over time pregnancy rates are increasing.

“Despite the pandemic being declared officially over, the aftershocks are still being felt as delays across other areas of healthcare prevent some patients accessing fertility services.

“Our report shows that the average age of IVF patients has increased to 36, around five years older than mothers who get pregnant naturally and these aftershocks could mean that the average age of an IVF patient continues to rise.

“Although pregnancy rates have increased, the likelihood of success decreases with age. For some patients, this may mean they never get the baby they hoped for and that’s heart breaking.”

The Fertility Treatment 2021: Preliminary Trends and Figures report also shows:

  • IVF cycles increased to 76,000 cycles in 2021 from almost 70,000 in 2019
  • There were 11 times more egg freeze cycles in 2021 than in 2011; 373 cycles in 2011 compared to 4,215 cycles in 2021. The number of embryo freeze cycles increased from 230 cycles in 2011 to 10,719 in 2021.
  • In 2021, the average IVF pregnancy rate using fresh embryo transfers for patients aged 18-34 was 41 per cent per embryo transferred with a birth rate of 33 per cent. This compares to six per cent for patients aged 43-50 when using their own eggs and a birth rate of four per cent.
  • Single patients and patients in female same-sex relationships had the largest increase in IVF usage from 2019 to 2021.
  • The use of private funding by patients across the UK aged 18-34 has continued to increase with 63 per cent of IVF cycles funded privately in 2021 compared to 52 per cent in 2019.
  • The number of IVF cycles funded by the NHS continued to vary across the UK with an overall decrease to 20,000 cycles in 2021 from around 24,000 in 2019 (-16 per cent).

The fertility sector is a unique area of healthcare in the UK as the majority of patients pay for treatment themselves.

The proportion of NHS funded cycles have decreased right across the UK between 2019 and 2021, with data showing a 17 per cent reduction of NHS funded IVF cycles in England, 36 per cent in Wales and one per cent in Scotland.

“There were just under 4,000 fewer IVF cycles funded through the NHS between 2019 and 2021 so although more people than ever are having fertility treatment, our data shows that more people than ever are now also paying for it,” explains Chain.

“There could be several reasons why NHS funded cycles lag behind those seen before the pandemic.

“Firstly, we’ve seen a change in the type of family accessing fertility treatment with clinics treating 44 per cent more single patients and 33 per cent more patients in same sex female couples in 2021 than they did in 2019.

“Secondly, funding criteria varies depending on where you live and under current rules, very few single and same sex patients qualify for NHS funding,” she continues.

“And finally, measures put in place during the Covid-19 pandemic saw clinics prioritise older patients and this combined with waiting list backlogs elsewhere in the NHS, could mean that women are no longer eligible for NHS funding by the time they are referred for fertility treatment.”

Fertility

Housing, work and fertility stop Britons having the families they want – research

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Housing, work and fertility pressures are stopping many Britons growing the families they want, new research suggests.

A UK fertility report found that 79 per cent of people surveyed who had tried to conceive in the past five years would like more children than they currently have.

Among parents with one child, that figure rises to 88 per cent.

The report surveyed more than 1,000 people across the UK who had tried for a baby in the past five years.

While birth rates continue to fall, the findings suggest it is not because people no longer want children. Instead, many respondents said external pressures are making it harder to grow their families.

The findings, from wellness brand Wild Nutrition’s Fertility Disconnect report, highlight how financial pressures, fertility struggles and gaps in reproductive health knowledge are shaping modern family life in the UK.

Gail Madalena, fertility nutritional therapist at Wild Nutrition, said: “People often assume fertility begins the moment they decide to try [for a baby].

“In reality, egg and sperm health are shaped months and years earlier.

“By the time someone starts thinking about fertility, their body has already been responding to its environment for a long time.”

Among the biggest barriers, 26 per cent said career progression affected their family plans, 25 per cent cited housing affordability and lack of space, and 52 per cent said they required medical intervention during their fertility journey.

The report also found that almost a quarter of respondents had spent more than two years trying to conceive.

Trying for a baby can take a significant toll on mental health and relationships, especially for those navigating fertility treatment.

According to the research, 38 per cent of respondents said trying to conceive had negatively affected their mental health. That figure rose to 99 per cent among people undergoing fertility treatment.

Julianne Boutaleb is a perinatal psychologist.

She said: “Navigating a fertility journey is about so much more than medical appointments and procedures.

“It’s an emotional marathon that can take a huge toll on your mental wellbeing.

“Sadly, the stats show that 15 per cent of couples going through fertility treatment say their relationship has been irrevocably impaired.”

The report also highlighted the realities of secondary infertility, which affects around one in 20 people, challenging the assumption that having one child means conceiving again will be straightforward.

Researchers found many people felt under-informed about fertility, particularly younger adults.

Ten per cent of Gen Z respondents said they “know nothing” about fertility, while only one in five respondents said they know “a lot” about egg health.

The report also found that 60 per cent of women were unaware of fertility testing options, and one in five Gen Z respondents said they felt uncomfortable discussing fertility, even with their partner.

Around 40 per cent of those surveyed supported fertility education being included in schools, covering topics such as egg health, sperm health and hormonal health.

The report also explored how lifestyle and long-term health may influence fertility outcomes.

Many respondents said they only made changes once they started trying to conceive.

Some 44 per cent improved their diet when trying for a baby, while 32 per cent reduced alcohol intake at that stage.

The report also referenced emerging research that suggests ultra-processed foods and microplastics could have an impact on reproductive health.

While fertility conversations often focus on women, the findings showed male fertility issues are also affecting many families.

Seventeen per cent of respondents cited sperm health issues as a barrier to conception, while male factors contribute to around half of all fertility challenges.

Only one in four men said they would share fertility struggles with friends.

“Many causes of male infertility are entirely treatable yet so often the last resort is the first response,” said Ian Stones, co-founder at Test Him Ltd.

The findings come as UK birth rates remain below replacement level.

The report noted that the UK fertility rate is now 1.41, meaning that on average women give birth to 1.41 children over their lifetimes. The replacement rate, or rate that maintains population numbers, is 2.1.

It also said the average age of mothers has risen to 31, while birth rates are falling across most age groups except among over-40s.

“There is no single fertility story, and it is rarely a simple, linear narrative,” said Dr Zeynep Gurtin, lecturer in women’s health at UCL.

Dr Gurtin added that better fertility education, fairer access to treatment and more open conversations around infertility and pregnancy loss are needed.

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Fertility

Femtech World reveals fertility innovation award shortlist

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Femtech World is thrilled to reveal the shortlist for the Fertility Innovation Award.

The award, sponsored by FinDBest IVF, celebrates a pioneering product, service or initiative that is transforming fertility care and support.

FinDBest IVF is a global B2B digital platform created to simplify and accelerate how IVF and ART manufacturers connect with trusted, pre-vetted distributors around the world.

This year’s nominees represent a remarkable breadth of approaches to fertility care: from clinic-floor breakthroughs to at-home hormone intelligence to truly borderless access.

Three companies made the cut, with each tackling a real, persistent barrier in reproductive health.

Congratulations to the shortlist and many thanks to everyone who entered.

Fertility Innovation Award Shortlist

 

HRC Fertility’s Needle-Free IVF is a pioneering advancement designed to transform one of the most challenging aspects of fertility treatment: daily hormone injections.

Developed by board-certified reproductive endocrinologist Dr Rachel Mandelbaum, this innovative approach reimagines how stimulation medications are delivered during IVF and egg freezing, dramatically improving the patient experience while maintaining the same trusted clinical outcomes.

Inspired by feedback from patients who struggled with the injection process, Dr Mandelbaum adapted an innovative drug-delivery system commonly used in other areas of medicine and applied it to reproductive care

Mira is a hormonal health technology company that provides lab-grade hormone testing and AI-driven insights to help women and couples understand their fertility. 

The platform has already supported more than 200,000 couples on their fertility journeys worldwide, helping over 60,000+ users achieve pregnancy.

For some users, pregnancy rates have reached up to 89 per cent within six months, demonstrating how accurate hormone data can significantly improve fertility outcomes.

 

Founded in 2021 by Marija Skujina, a Certified Fertility Nurse Specialist accredited by the European Society of Human Reproduction and Embryology, with nearly 15 years of clinical experience at one of the world’s top IVF clinics, and having navigated her own fertility journey as a patient, Marija built the clinic she had always wished existed.

Plan Your Baby began with a bold, but simple mission – make best quality fertility and pregnancy available anywhere.

Plan Your Baby has created a new generation fertility and pregnancy clinic with patients accessing expert consultations remotely, while blood tests and ultrasound scans are available at over 450 locations across the UK, eliminating the exhausting travel burden that often forces people to take days off work, relocate appointments, or abandon treatment altogether

What happens now

The shortlist will be judged by a representative from category sponsor FindBestIVF, with the winner announced at a virtual event on June 19.

Winners will receive a trophy and be interviewed by a Femtech World journalist.

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Fertility

First patients dosed in miscarriage trial

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The first patients have been dosed in a UK miscarriage trial testing a new intravaginal drug delivery platform for threatened miscarriage.

The FREEDOM study is evaluating 400mg progesterone Callavid in patients diagnosed with luteal phase insufficiency, a condition in which progesterone levels may be too low to support early pregnancy, increasing the risk of infertility and recurrent miscarriage.

Callavid uses a patented leak-free, tampon-like design intended to address the limitations of current vaginal treatments, which rely on self-administered pessaries, or vaginal suppositories, that can leak and may move during use.

The device is being developed by London-based Calla Lily Clinical Care, a medical technology company focused on women’s health. The trial is funded by the National Institute for Health and Care Research and run in collaboration with the Trial Management Unit at University Hospitals Coventry and Warwickshire NHS Trust.

According to the company, Callavid is positioned to become the world’s first drug-device combination product to support treatment of threatened miscarriage, as well as luteal phase support as part of assisted reproductive technologies, including in vitro fertilisation, or IVF.

The Government’s Renewed Women’s Health Strategy for England cites estimates ranging from 120,000 to 250,000 cases of miscarriage a year in the UK. Administering 400mg micronised progesterone twice daily is recommended by the National Institute for Health and Care Excellence for women who have suffered a previous miscarriage and experience bleeding during early pregnancy, known clinically as threatened miscarriage.

Current pessary delivery methods can result in uncertain placement and movement during use. These limitations can reduce the efficiency and consistency of drug absorption, potentially compromising delivery of the intended dose, and patients are regularly advised to lie horizontal for extended periods after each administration.

The FREEDOM trial is led by professor Siobhan Quenby MBE, an authority on miscarriage and preterm birth, and an honorary consultant at University Hospitals Coventry and Warwickshire NHS Trust. The study aims to evaluate safety, user acceptability and progesterone absorption, with the goal of providing evidence of improved usability in self-administration.

Quenby commented: “Through my clinical practice, I see the difficulties patients face with existing vaginal progesterone products at an already very stressful time. Callavid offers a promising new solution to ensure delivery of the correct progesterone dosage and give women greater confidence in their treatment. There is genuine excitement among both clinicians and patients at the prospect of Callavid progressing into clinical trials.”

Dr Lara Zibners, co-founder and chair of Calla Lily Clinical Care, added: “As a physician and entrepreneur, I believe we have a responsibility to create more effective, patient-centred solutions in women’s health. Having been through seven rounds of IVF myself, I have experienced how difficult progesterone treatment can be, and I am proud to be advancing an innovation shaped by both medical insight and lived experience.”

Thang Vo-Ta, co-founder and chief executive of Calla Lily Clinical Care, said: “Dosing the first patients in the FREEDOM study marks a critical milestone for Calla Lily Clinical Care. Callavid represents a differentiated delivery modality for a broad range of therapeutics in the pharma pipeline, and will create new opportunities to extend the lifecycle of existing drugs. This trial is a key step in demonstrating Callavid’s massive potential.”

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