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Australian researchers to develop new test for ovarian cancer

If successful, the test has the potential to improve early evaluation, speed up diagnosis and lower healthcare costs

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Australian researchers are working on a new blood test to improve ovarian cancer diagnosis, with the potential to reduce unnecessary surgery.

The test, developed by scientists at Hudson Institute of Medical Research and commercialised by Cleo Diagnostics, will be underpinned by a novel biomarker, CXCL10, which is produced early and at high levels by ovarian cancers, but not in non-malignant disease.

The solution is hoped to accurately distinguish benign from malignant disease without surgical intervention. If successful, it has the potential to improve early evaluation, speed up diagnosis, lower healthcare costs and reduce stress and anxiety associated with a surgical diagnosis.

Ovarian cancer is the most lethal of all cancers affecting women in Australia. The current five year survival rate is 49 per cent and this has not changed substantively in 50 years.

Ovarian cancers are often indistinguishable from common, non-cancerous disease. Currently patients undergo a combined blood test and ultrasound to provide an assessment of disease.

However, experts argue neither is sufficient for an accurate diagnosis and they are only used for surgical referral.

As there is no accurate detection test for ovarian cancer, surgery to remove the ovaries remains the only way to diagnose the presence of malignant disease.

“There is often a delay in sending patients to a gynaecological oncology specialist for treatment, because defining whether a growth is likely to be malignant or not before surgery is very difficult,” explained Professor Tom Jobling, lead medical advisor at Cleo Diagnostics.

“This new test will help ensure that an optimal management plan can be put in place early, which will streamline the referral process and provide the best care for patients.

“This also extends to patients with benign conditions, where early identification will permit direction to more appropriate use of resources.”

Hudson Institute’s CEO, Professor Elizabeth Hartland, added: “Hudson Institute is delighted to be partnering with Cleo Diagnostics to take our work on ovarian cancer one step closer to delivering a much-needed diagnostic test.”

Initial clinical use of the test, the researchers have said, will focus on the surgical triage market to improve treatment outcomes for patients with ovarian cancer, and avoid unnecessary surgery and anxiety for women with far more common non-cancerous conditions.

Beyond surgical triage, Cleo Diagnostics will conduct further clinical trials to evaluate the effectiveness of the underlying core technology for disease recurrence following surgery, aiming to develop broader screening applications in the general population.

Diagnosis

Women gaslit over hysteroscopy pain, Mumsnet posts reveal

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Women have described being dismissed and left in serious pain during routine hysteroscopy examinations, with many given little or no pain relief.

Users of parenting forum Mumsnet who underwent hysteroscopy procedures also shared concerns about receiving unclear information before treatment and being given little or no pain relief afterwards.

Some women, who described feeling physically and emotionally vulnerable, compared the experience to sexual assault.

Research led by the University of Reading analysed 4,644 posts from Mumsnet users written between 2018 and 2024.

Susanne Cromme, lead author from the University of Reading, said: “Women in their thousands say they are going into hysteroscopy procedures unprepared, left in more pain than they were led to expect, and feeling that their experience is not being taken seriously, our analysis shows.

“This is not simply an online pile-on. The themes we found in our research are consistent with what clinical studies already tell us about hysteroscopy.

“But by listening to women talk to each other openly, without a researcher in the room, we get a much richer picture of the issues facing patients.”

The study was published following the launch of the Mumsnet campaign to End Medical Misogyny, which is fighting to end the “systemic dismissal, disbelief or de-prioritisation of women’s symptoms in healthcare”, and comes after health secretary Wes Streeting said the health system “too often gaslights women, treating their pain as an inconvenience.”

Justine Roberts, founder of Mumsnet and Gransnet, said: “This research makes clear that too many women are still experiencing severe pain during hysteroscopy, and that problem is compounded by unclear information, inconsistent pain relief and a lack of proper consent.

“These are not one-off failures, they form a repeated pattern and that’s exactly what Mumsnet’s medical misogyny campaign is highlighting: systemic failings in women’s healthcare.

“Nothing encapsulates that more clearly than the expectation that women should endure avoidable pain during gynaecological procedures. If the NHS is serious about tackling medical misogyny, this has to change.”

Around 71,000 hysteroscopy procedures take place every year in England.

According to the analysed Mumsnet posts, women were told procedures would be no worse than a smear test, felt unable to stop once they had started and found that the pain relief available depended entirely on which NHS trust they attended.

The analysis identified five recurring problems among hysteroscopy patients: not enough information before the procedure; women feeling exposed and unprotected; a “postcode lottery” for pain relief, with wide variation between trusts; pain being played down by staff; and an unequal standard of care.

Women also questioned why sedation routinely offered for procedures such as colonoscopies and endoscopies, which examine the bowel and digestive tract, was not available for gynaecological procedures.

The researchers said the findings suggest the problems go beyond individual clinicians, as the posts reflect wider structural issues in women’s healthcare, including potentially underfunded services and unequal standards of care.

The study calls for NHS trusts to introduce standardised consent processes that give women clear information about pain, alternatives and what to expect.

It also recommends consistent pain management protocols across all hospitals, and training for clinicians in trauma-informed care.

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Menopause

Uni initiative tackles women’s health crisis

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A University of Sheffield initiative is tackling overlooked women’s health problems by helping students develop solutions to delays and inequalities in care.

In a first-of-its-kind collaboration bringing together students, clinicians and industry leaders, new ideas have been developed to address health challenges that leave millions of women facing years-long delays in diagnosis and care.

The Women’s Health Innovation Challenge saw 50 students from across disciplines and year groups work in teams on issues including fragmented care across the female health lifecycle and the widespread normalisation of serious symptoms.

Among the key challenges explored was endometriosis, a condition affecting one in 10 women globally, where patients in the UK face an average diagnosis time of more than nine years.

Other innovations addressed gaps in menopause care, cardiovascular health in women and the fragmentation of digital health solutions across different life stages.

The initiative reflects the university’s growing work in women’s health innovation, a field widely recognised as underfunded and underserved despite affecting half the global population, and its commitment to turning research and ideas into meaningful impact.

Rachel Kovacs, a final year biomedical engineering student at the University of Sheffield and organiser of the event, said: “I was lucky enough to be one of the students to take the first Women’s Health in Biomedical Engineering module in the UK, right here in Sheffield, and it really opened my eyes to how under-innovated the field is.

“I only discovered this in my final year and I wanted other students to find it sooner.

“The event itself has already made a huge difference. Students now see women’s health as a space worth innovating in.

“If even a handful take their ideas further, we could genuinely change women’s lives.

“Having personally experienced some of these gaps, I know the impact this could have on women across the globe.”

The event was supported by experts from across research, industry and healthcare, including panel members from Health Innovation Yorkshire & Humber, an NHS England organisation which acts as a bridge between healthcare providers, commissioners, academia and industry.

Participants explored a range of possible solutions to some of the sector’s most complex challenges.

The event culminated in students pitching their ideas to a panel including clinicians, academic researchers and founders of women’s health startups, creating a direct link between emerging innovation and real-world application.

The challenge forms part of the university’s wider activity in this space, including its Women’s HealthTech Innovation Network, which brings together regional and national expertise to translate research into solutions that address longstanding inequalities in care.

Dr Vanessa Hearnden, senior lecturer in biomaterials and tissue engineering at the University of Sheffield and co-chair of the Women’s HealthTech Innovation Network, said: “The Women’s Health Innovation Challenge gave students a rare opportunity to work directly with clinicians, researchers and industry partners to tackle real-world problems.

“The quality of ideas and level of engagement demonstrated the impact this kind of interdisciplinary, challenge-led learning can have.”

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Resistance training has preventative effects in menopause, study finds

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Resistance training improves hip strength, balance and flexibility during menopause and may also improve lean body mass, research suggests.

A study of 72 active women aged 46 to 57 found those who completed a 12-week supervised programme saw greater gains than those who kept to their usual exercise routines.

None of the participants were taking hormone replacement therapy.

The supervised, low-impact resistance exercise programme focused on strength at the hip and shoulder, dynamic balance and flexibility.

Participants used Pvolve equipment, including resistance bands and weights around the hips, wrists and ankles, and also lifted dumbbells of varying loads.

Women in the resistance training group showed a 19 per cent increase in hip function and lower-body strength, a 21 per cent increase in full-body flexibility and a 10 per cent increase in dynamic balance, meaning the ability to stay stable while moving.

Those in the usual activity group did not show any significant improvements.

Previous studies have assessed the decline in lower limb strength and flexibility during menopause, but this is said to be the first study to compare the effect of resistance training on muscle strength and mass before, during and after menopause.

This was done by including participants in different phases of menopause rather than following the same participants over a long timeframe.

Francis Stephens, a researcher at the University of Exeter Medical School in the UK, said: “These results are important because women appear to be more susceptible to loss of leg strength as they age, particularly after menopause, which can lead to increased risk of falls and hip fractures.

“This is the first study to demonstrate that a low-impact bodyweight and resistance band exercise training programme with a focus on the lower limbs, can increase hip strength, balance, and flexibility.

“Importantly, these improvements were the same in peri- and post-menopausal females when compared to pre-menopausal females, suggesting that changes associated with menopause do not mitigate the benefits of exercise.”

Although one of the researchers sits on Pvolve’s clinical advisory board, the researchers said the company did not sponsor the study or influence its results.

Stephens added that any progressive resistance exercise training focused on lower-body strength is likely to yield the same results.

He said: “The important point is for an individual to find a type of exercise, modality, location, time of day etc., that is enjoyable, sustainable, and improves everyday life.

“The participants in the present study reported an improvement in ‘enjoyment of exercise,’ and some are still using the programme since the study finished.”

Kylie Larson, a women’s health and fitness coach and founder of Elemental Coaching, who was not involved in the study, said the results were compelling.

She said: “This is particularly exciting for those that tend to think of menopause as ‘the end’. The study proves that if you incorporate strength training you can still make improvements to your muscle mass and strength, which will also have a positive ripple effect to your ability to manage your body composition.

“In addition, staying flexible and being able to balance are both keys to a healthy and functional second half of life.”

Participants in the study did four classes a week for 30 minutes each session, but Larson said even half that amount of strength training can go a long way, particularly if you emphasise progressive overload, which means gradually increasing muscle challenge through more weight.

Larson said: “Gradually increasing the challenge is what drives real change.

“Lifting heavier over time is what builds strength, protects your bones, and keeps your body resilient through menopause and beyond.”

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