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Zilico device increases cervical cancer detection by up to 24 per cent

The diagnostic tool is able to identify cell changes that cannot always be seen with standard colposcopy

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ZedScan is a diagnostic system used as an adjunct to standard colposcopy

The use of ZedScan in diagnostic screening has significantly increased the detection of cancer and potential cancer, according to the European Journal of Obstetrics & Gynecology and Reproductive Biology.

Part of Zilico, the British diagnostic technology for cervical cancer, ZedScan is an adjunct diagnostic device which uses Electrical Impedance Spectroscopy (EIS) technology to identify cell changes that cannot always be seen with standard colposcopy, providing immediate and accurate diagnosis of tissue which may be abnormal.

At colposcopy, clinicians look for cervical intra-epithelial neoplasia (CIN) or abnormal changes of the cells that line the cervix. These changes may be high or low grade.

With ZedScan, the biggest increase in cancer detection was found in women referred with low grade changes – often the most challenging to visualise – where the device had over a 50 per cent increase in high grade disease detection.

Already used by some NHS trusts and hospitals across Finland, the diagnostic tool will help provide better outcomes for women across the globe.

The cervical screening process screens for HPV infection. Those with HPV are then referred for colposcopy. In addition to traditional colposcopy methods, many NHS trusts have started using ZedScan for improved diagnostic information provided in real-time.

“It is fantastic news for patients in the UK and further afield,” says Sameer Kothari, Zilico CEO.  “Colposcopy has not materially changed for nearly 100 years and this data shows how having this advanced technology at the point of examination during colposcopy helps patients, clinicians and hospitals.

“Not only is this technology meaningful for the patient’s comfort and reassurance, it is quite simply detecting more problems accurately, and in greater detail, allowing people to access the treatment that they need more efficiently. This is important research here in the UK and Europe and has huge potential for the rest of the world and developing economies where cervical cancer often goes undetected.”

For more info, visit zilico.co.uk.

Diagnosis

Breast cancer patients face ‘postcode lottery’ for new drug

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Breast cancer patients in Scotland face a postcode lottery that could limit access to two newly approved NHS treatments.

The Scottish Medicines Consortium has approved Elacestrant and Capivasertib, which could be life-extending for some people with metastatic breast cancer.

Eligibility depends on genetic testing to confirm gene mutations before treatment can be prescribed, but the necessary testing is not yet available through the NHS in Scotland.

The testing is available to patients in England and to those able to pay for it privately.

Claire O’Donnell, who was diagnosed with metastatic breast cancer at 37, has raised concerns about the difference in access.

Ten years after her diagnosis, O’Donnell is receiving a treatment that works for her but does not know when it may stop being effective.

She said: “I know how lucky I am. It’s certainly not been easy but I’m incredibly lucky and incredibly privileged to be in that position.

“I’ve watched a lot of my friends die, and a lot of the circumstances has been about not being able to access a drug or getting the drug too late or being too poorly by the time the drug becomes available to them. It makes me angry, and it makes me sad.”

O’Donnell, who has been supported by secondary breast cancer charity Make 2nds Count, is frustrated by the gap in care for patients in Scotland.

She said: “These drug are a lifeline to people. It makes all the difference, and it only takes one drug to be your drug that you know can give you six months a year, two years, five years. It’s almost like they’ve given you a bit of good news, but they’ve also put a little bit of a criteria on it that you know they dangle the carrot in front of you.”

David Cameron, professor of oncology at Edinburgh University and chair of trustees for Make 2nds Count, said the system needed improving to better support patients.

He said: “It’s a frustration for many of us in the clinic because for a long time we’ve been saying as we move into an era of medicines, not just cancer medicines, but medicines that are increasingly driven by special tests, we need a system which absolutely locks the two things together.

“There has been progress in that direction, but they’re not locked together. this comes down to the way the NHS is in a sense fragmented internally.”

Health secretary Angela Constance said: “I welcome the acceptance of Elacestrant, known as Korserdu, for treatment of post-menopausal women, and men, with a certain type of advanced breast cancer.

“We work closely with the independent SMC and the NHS in Scotland to improve access to new medicines, helping to expand the range of treatment options available.

“We are aware that a genomic test is needed in order to access this therapy, and we are working in collaboration with the NHS and industry partners to secure access to this as soon as possible.”

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Diagnosis

New test could cut need for invasive womb cancer checks

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A urine and vaginal fluid test could help rule out womb cancer in women with postmenopausal bleeding, potentially reducing invasive checks.

In a study of 1,864 women with postmenopausal bleeding, the test identified 80 of 99 womb cancers and correctly gave a negative result for 93 per cent of women without the disease.

Researchers said the test was not accurate enough to rule out cancer on its own, but could help fast-track women at the highest risk for urgent investigation while reducing immediate invasive testing for those at lower risk.

Professor Emma Davidson, of the University of Manchester and Manchester University NHS Foundation Trust, said: “Bleeding after the menopause is understandably alarming for women because it can be a sign of cancer, but the vast majority of those investigated will not have the disease.

“At the moment, many women face invasive, uncomfortable tests that can be stressful as well as costly for health services before cancer can be ruled out.

“Our study shows that a simple test using urine and vaginal samples could help identify the women most likely to have cancer while safely reassuring many others much earlier in the diagnostic pathway.

“If further studies confirm these findings in routine practice, this approach has the potential to transform care for thousands of women every year.”

Developed at the University of Manchester and Manchester University NHS Foundation Trust, the test examines cells collected from urine and vaginal fluid samples.

Postmenopausal bleeding currently triggers an urgent cancer referral, although only about 5 to 10 per cent of women who report it have an underlying cancer.

Current investigations include an internal ultrasound scan, a biopsy of the womb lining and hysteroscopy, in which a camera is passed into the womb.

Women taking part in the study attended seven hospitals in north-west England and provided urine and vaginal fluid samples before undergoing their routine tests.

Five per cent of participants, 99 of 1,864 women, were diagnosed with womb cancer through biopsy or surgery.

Cytologists assessed the samples without knowing the women’s diagnoses.

Researchers said the test could be used to triage women suspected of having womb cancer, with lower-risk patients monitored through repeat sampling or given a full assessment if symptoms continued.

They cautioned that the samples were assessed by highly trained specialist cytologists, so it is not yet known whether the same accuracy could be achieved in other settings.

The test has also not been studied in women without symptoms.

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Insight

Trust apologises for ‘human error’ after maternity data loss

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Nottingham University Hospitals NHS Trust has apologised after a human error caused 11 years of maternity data to be overwritten.

The incident happened during routine technical work on 18 August, when computer instructions intended to create a copy of a radiotherapy database were mistakenly applied to the maternity database.

Most of the affected information has since been recovered, including notes, observations, test results and other information recorded as part of patient care.

However, the trust has been unable to fully restore the historical record showing who viewed maternity records between September 2011 and November 2022.

Current data was not affected and the incident has had no impact on current maternity services or care provided to women and babies, according to the trust.

It also said no information was accessed or used inappropriately as a result of the incident.

Andy Callow, chief digital and information officer at Nottingham University Hospitals, said: “I am sorry for the concern and distress this incident may cause to women and families affected.

“On 18 August 2026, a human error during a routine technical process resulted in a maternity records database being unintentionally overwritten.

“We took immediate action to investigate the incident and recover the affected information.

“The information needed to support patient care has been restored and there has been no impact on current maternity services or the care provided to women and babies today.

“However, to date, we have been unable to fully restore the historical record showing who viewed maternity records between September 2011 and November 2022.

“We have informed the Information Commissioner’s Office, completed a full investigation and strengthened our processes and controls to help prevent a similar incident from happening again.”

The error occurred when pre-written computer instructions previously used for another hospital system were used during the technical work.

A setting that should have been changed was not altered, resulting in work being carried out on the maternity database instead of the radiotherapy database.

The issue was escalated within minutes of being identified and experts were brought in to recover as much information as possible.

The trust has referred the incident to the Information Commissioner’s Office and notified Nottinghamshire Police, which is conducting a separate criminal investigation into maternity care at the trust.

The force is assessing whether the loss of information about who accessed maternity records could affect that investigation.

The incident follows a maternity review led by midwife Donna Ockenden, which concluded in June after examining the cases of 2,500 families over a 20-year period.

The review found more than 500 mothers and babies suffered potentially avoidable harm, with 162 dying following substandard care. Some babies who survived were left seriously disabled.

Nottinghamshire Police announced its separate criminal investigation, Operation Perth, in September 2023.

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